Most studies on entrepreneurial orientation (EO) have focused on developed countries, leaving emerging economies relatively underexplored despite their high entrepreneurial activity. This paper seeks to systematise the literature on EO across Latin America and the USA. A bibliometric analysis was conducted on 75 manuscripts from the Scopus database, complemented by a comparative literature analysis of 36 relevant papers. The results show that 75 articles were published across 53 journals, among which the Journal of Small Business and Enterprise Development accounts for five articles and 203 citations. Moreover, most of the manuscripts were published ten years ago or less, with a peak of publications in 2020, mainly from the USA. A thematic map revealed five key clusters of research: competitive advantage, entrepreneurship, internationalisation, sustainability, and management practices, whose content the literature review helped to clarify. From these findings, several research propositions were formulated, offering future directions for EO studies in emerging economies.