This study aims at describing a practical and successful application of a university social responsibility (USR) and sustainability program management model run by a business school in partnership with public-private financial institutions. It focuses on the positive impacts on women microentrepreneur leaders in small and medium-sized enterprises (SMEs) of the “Woman, help your business grow further [Mujer, que tu negocio crezca más]” program. The value of social intervention programs and applied research as part of a university social responsibility strategy stands out. Research was conducted through a qualitative approach, including in-depth interviews with company executives and focus groups with women microentrepreneurs participating in the program. There were relevant outcomes regarding empowerment, managerial capacities, and the sustainability of their enterprises.